结直肠癌患者肠道菌群特征研究
首发时间:2023-05-12
摘要:结直肠癌是十分常见且具有高致死率的癌症。结直肠癌的发生与肠道菌群有着密不可分的关系。目的:分析结直肠癌患者肠道菌群的特征,探索诊断结直肠癌的菌群潜在标志物。方法:对肠道的16S rRNA进行测序,对比结直肠癌患者与健康人肠道菌群的构成改变。结果:结直肠癌患者肠道菌群β多样性与健康人群有显著差异。结直肠癌患者肠道拟杆菌属、普雷沃属菌属丰度发生改变。埃希菌、γ-变形菌、变形菌、肠杆菌属、肠杆菌目、细菌门可作为结直肠癌潜在的菌群潜在标志物。
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Characteristics of intestinal flora in patients with colorectal cancer
Abstract:Colorectal cancer is a very common cancer with high mortality. The occurrence of colorectal cancer is closely related to intestinal flora. Objective: To analyze the composition of intestinal flora in patients with colorectal cancer, and to find out the biomarkers for the diagnosis of colorectal cancer. Methods: Intestinal 16S rRNA was sequenced to compare the composition of intestinal flora between colorectal cancer patients and healthy people. Results: The diversity of intestinal flora β in colorectal cancer patients was significantly different from that in healthy people. The abundance of Bacteroides and Prevoides in colorectal cancer patients was changed. Escherichia, gamma-Proteus, Proteus, Enterobacteriaceae, Enterobacteriaceae and Bacteria can be used as potential markers of colorectal cancer.
Keywords: colorectal cancer Intestinal flora 16S rRNA
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结直肠癌患者肠道菌群特征研究
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